生理基因組學公布了從人類和信息模型系統到連接基因和生理途徑的技術，從原核生物到真核生物的各種研究結果。該雜志鼓勵提交將基因與細胞復制、發育、代謝功能、細胞信號轉導和細胞內信號通路、組織和器官功能以及整個生物體功能聯系起來的研究報告。生理基因組學鼓勵使用表達譜分析、分子相互作用分析、自然和定向基因改變、選擇性育種研究、基因鑒定和基因/環境相互作用評估等方法。該雜志歡迎加強功能基因組學研究的重要新技術和概念。該雜志鼓勵發表新的計算方法、綜合模型和基因功能的圖像分析預測。生理基因組學也發表了一些評論和觀點，以加強對遺傳學和生理學之間聯系的理解。期刊致力于快速同行評審，確保發表高質量的論文和及時的新聞評論文章。

Physiological Genomics publishes results of a wide variety of studies from human and from informative model systems with techniques linking genes and pathways to physiology, from prokaryotes to eukaryotes. The Journal encourages the submission of research that links genes to cell replication, development, metabolic function, cell signal transduction and intracellular signaling pathways, tissue and organ function, and whole organism function. Physiological Genomics encourages the utilization of approaches ranging from expression profiling, assays for molecular interactions, natural and directed gene alteration, selective breeding studies, gene identification, and the assessment of gene/environment interaction. The Journal welcomes important new technologies and concepts that enhance the study of functional genomics. The Journal encourages publication of new computational approaches, integrative models, and image analysis predictive of gene function. Physiological Genomics also publishes invited reviews and perspectives that enhance the understanding of the link between genetics and physiology. The Journal is committed to rapid peer review to ensure the publication of high-quality papers and timely news and review articles.