《蛋白質組研究雜志》的內容涵蓋全球蛋白質分析和功能的所有方面，包括基因組學、時空蛋白質組學、代謝組學和代謝組學、臨床和農業蛋白質組學以及生物信息學等方法學的進展。主題和重點是通過不同類型的“組學”之間的協同作用，對生命科學進行多學科研究。

Journal of Proteome Research publishes content encompassing all aspects of global protein analysis and function, including the dynamic aspects of genomics, spatio-temporal proteomics, metabonomics and metabolomics, clinical and agricultural proteomics, as well as advances in methodology including bioinformatics. The theme and emphasis is on a multidisciplinary approach to the life sciences through the synergy between the different types of "omics".