《美國生理學雜志：心臟和循環生理學》發表了對心臟、血管和淋巴管的生理學的原始研究，包括從完整的動物到細胞、亞細胞等各個層次的心血管功能的實驗和理論研究，以及分子水平。它包含了對這些功能及其控制系統的新描述，以及它們在生物化學、生物物理學、遺傳學和細胞生物學中的基礎。研究提供了對決定心臟和循環的正常和不正常表現的機制的新的重要見解。

The American Journal of Physiology: Heart and Circulatory Physiology publishes original investigations on the physiology of the heart, blood vessels, and lymphatics, including experimental and theoretical studies of cardiovascular function at all levels of organization ranging from the intact animal to the cellular, subcellular, and molecular levels. It embraces new descriptions of these functions and of their control systems, as well as their bases in biochemistry, biophysics, genetics, and cell biology. Preference is given to research that provides significant new insights into the mechanisms that determine the performance of the normal and abnormal heart and circulation.