《普通生理學和生物物理學》每季出版一次，致力于在細胞和分子水平上發表與普通生理學，生物物理學和生物化學相關的原始研究論文。該期刊的報道包括：膜生理學和生物物理學（離子通道，受體，轉運蛋白，蛋白質 - 脂質相互作用，表面現象，模型膜），細胞間和細胞內信號傳導（神經傳遞，內分泌調節，信使，分泌機制，調節蛋白，鈣）信號通路，一氧化氮），興奮性和收縮性（神經生理學，平滑，心肌和骨骼肌生理學，激發 - 收縮耦合，細胞運動），細胞功能的生物物理分析（生物能量學，體積調節，熱力學，數學模型），代謝調節（酶學，ATP酶，植物和微生物代謝），藥理學，毒理學和病理學的細胞方面（受體 - 藥物相互作用，藥物和毒素對信號和調節功能的作用，自由基，脂質過氧化，缺血預處理，鈣悖論），有關技術和方法的進展情況。

General Physiology and Biophysics appears quarterly and is devoted to the publication of original research papers concerned with general physiology, biophysics and biochemistry at the cellular and molecular level. The coverage of the journal includes: membrane physiology and biophysics (ion channels, receptors, transporters, protein-lipid interactions, surface phenomena, model membranes), intercellular and intracellular signalling (neurotransmission, endocrine regulations, messengers, secretory mechanisms, regulatory proteins, calcium signalling pathways, nitric oxide), excitability and contractility (neurophysiology, smooth, cardiac and skeletal muscle physiology, excitation-contraction coupling, cellular motility), biophysical analysis of cellular function (bioenergetics, volume regulation, thermodynamics, mathematical models), metabolic regulations (enzymology, ATPases, plant and microbial metabolism), cellular aspects of pharmacology, toxicology and pathology (receptor-drug interaction, the action of drugs and toxins on signalling and regulatory functions, free radicals, lipid peroxidation, ischemic preconditioning, calcium paradox), accounts of advances in relevant techniques and methodology.