計算生物學和化學在計算生命科學的所有領域出版原始研究論文和評論文章。特別歡迎在核酸和蛋白質序列研究、分子進化、分子遺傳學(功能基因組學和蛋白質組學)、生物特異性或化學生物特異性建模的理論和實踐以及核酸和蛋白質的結構生物學等領域提供高質量的研究成果，這些研究成果是計算方面的重要組成部分。在生物信息學、系統生物學、生態學、計算藥理學、代謝、生物醫學工程、流行病學和統計遺傳學方面的高質量研究工作也將被考慮。鑒于它們固有的不確定性，蛋白質模型和分子對接研究應該得到徹底的驗證。在缺乏實驗結果進行驗證的情況下，例如，應該使用分子動力學模擬和詳細的自由能計算作為補充技術來支持主要結論。沒有額外的生物學見解的不成熟的模型練習的提交將不被考慮。評審文章一般由編輯委托撰寫，未經明確邀請不得投稿。然而，歡迎未來的作者發送一個簡短的(一到三頁)概要，這將由編輯進行評估。

Computational Biology and Chemistry publishes original research papers and review articles in all areas of computational life sciences. High quality research contributions with a major computational component in the areas of nucleic acid and protein sequence research, molecular evolution, molecular genetics (functional genomics and proteomics), theory and practice of either biology-specific or chemical-biology-specific modeling, and structural biology of nucleic acids and proteins are particularly welcome. Exceptionally high quality research work in bioinformatics, systems biology, ecology, computational pharmacology, metabolism, biomedical engineering, epidemiology, and statistical genetics will also be considered.Given their inherent uncertainty, protein modeling and molecular docking studies should be thoroughly validated. In the absence of experimental results for validation, the use of molecular dynamics simulations along with detailed free energy calculations, for example, should be used as complementary techniques to support the major conclusions. Submissions of premature modeling exercises without additional biological insights will not be considered.Review articles will generally be commissioned by the editors and should not be submitted to the journal without explicit invitation. However prospective authors are welcome to send a brief (one to three pages) synopsis, which will be evaluated by the editors.