這份及時的國際期刊旨在提供一個論壇，用于介紹與毒理學反應的化學基礎的所有方面有關的研究。它發表論文，專門研究識別新的毒劑和活性中間體，制定具體和敏感的新方法，以檢測生物大分子被毒劑改變的情況，描述大分子結構和功能與化學劑相互作用的變化，對控制與特定大分子反應的化學因素的實驗和理論研究，以及有毒物質的代謝，因為它有助于它們的生物效應。毒物學中的化學研究發表關于化學制劑毒物學效應研究的結構、機理和技術進展的文章、通信、應邀評論和觀點。 此外，還每年出版一期題為"論壇"的專題節目。

This timely, international journal is intended to provide a forum for presentation of research relevant to all aspects of the chemical basis of toxicological responses. It publishes papers devoted to identification of novel toxic agents and reactive intermediates, development of specific and sensitive new methods for detection of modification of biological macromolecules by toxic agents, characterization of the alteration of macromolecular structure and function by interaction with chemical agents, experimental and theoretical studies of chemical factors that control reactivity with specific macromolecules, and metabolism of toxic agents as it contributes to their biological effects. Chemical Research in Toxicology publishes Articles, Communications, Invited Reviews, and Perspectives on structural, mechanistic, and technological advances in research related to the toxicological effects of chemical agents. In addition, a feature entitled Forum is published once a year.